Clear cell odontogenic carcinoma ccoc is an infrequent tumor, which is aggressive by nature among the odontogenic tumors. Pdf clear cell odontogenic carcinoma of mandible sherin. Fewer than 30 reported cases have appeared in the english literature since its first description in 1985 by hansen et al. The rarity of this tumor, occurrence in maxilla and young age of the patient are some of the rare features which need documentation. Pdf clear cell odontogenic carcinoma of the maxilla. May 01, 2003 clear cell odontogenic carcinoma ccoc is a rare central malignancy of the jaws.
Introduction calcifying epithelial odontogenic tumor ceot was first described as a segmented disease in 1955 by pindborg. Clear cell odontogenic carcinoma archives of pathology. May 24, 20 we present an uncommon case female patient aged 59 years of the clear cell variant of calcifying epithelial odontogenic tumor ceot also known as pindborg tumor in the mandible. A rare case of clear cell odontogenic carcinoma was investigated using histochemical and immunohistocheinical methods. It accounts for less than1% of all odontogenic neoplasms. Since then, the predominance of the clear cell component in ceots has been reported mainly through single cases and its prognostic importance is still debatable 18. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates. The predominant histologic finding of islands of epithelial cells with clear to finely eosinophilic cytoplasm is not unique to this tumor. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor. Microscopically, the tumor mainly consisted of clear, glycogen. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma.
Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw which was first described as a clear cell odontogenic tumor in 1985 by hansen 1. Although there are numerous reports on the variants of ceot, occurrence of clear cells with complete absence of calcification has been a rarity. Jan 01, 2016 clear cell odontogenic carcinoma ccoc is a rare neoplasm, with 79 cases reported in english literature till date. Odontogenic neoplasms of predominately clear cells are unusual. Jun 16, 2004 a case of odontogenic ghost cell tumour ogct with clear cell components was encountered in the mandible of a 63. The clear a rare odontogenic benign tumor, occasionally inva epithelial cells contain glycogen, as demonstrated by the sive, which produces a homogeneous, eosinophilic, periodic acidschiff pas reaction, which is removed by palestaining amyloidlike material which may become diastase digestion. Sep 24, 2015 background clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaw with a particular histology and a deceptive behaviour. It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Calcifying epithelial odontogenic tumor ceot is a solid, locally aggressive, benign odontogenic neoplasm characterized by sheets and nests of polyhedral epithelial cells exhibiting eosinophilic and less often clear cytoplasm, occasional nuclear pleomorphism without mitotic activity, calcifications, and deposits of amyloid. The clear cell odontogenic tumor cot, a rare epithelial tumor of putative odontogenic origin, was first characterized by hansen et al.
Ccoc was initially known as clear cell odontogenic tumor or clear cell ameloblastoma. The tumor was surgically excised and has not recurred or metastasized 6 months after surgery. They represent a diagnostic dilemma, and as a result, treatment strategies are diverse. Incisional biopsy showed a malignant jaw bone tumor, therefore composite resection including partial mandibulectomy, left supraomohyoid lymph node dissection. Clear cell odontogenic carcinoma ccoc is described as an exceptional and hard to diagnose malignant tumor which was first. The tumor cells were large, with clear cytoplasm, and arranged in irregular sheets. To date, only 107 cases have been reported in the literature since its first description by hansen et al. Pdf clear cell variant of calcifying epithelial odontogenic.
Clear cell odontogenic carcinoma ccoc is described as an exceptional and hard to diagnose malignant tumor which was. Our cases included 4 men and 2 women with an average age of 52. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5 th 7 th decades and shows a. Clear cell odontogenic carcinoma ccoc is histologically characterized by solid sheets and nests of clear cells. The importance of its diagnosis and various differential diagnoses are discussed. Clear cell variant of calcifying epithelial odontogenic tumor. Our goal is to present two new cases, summarize reported cases of clear cell odontogenic carcinoma ccoc, assess potential risk factors for recurrence, and propose definitive surgical and therapeutic strategies. Calcifying epithelial odontogenic tumor ceot is a rare, benign, locally aggressive odontogenic epithelial tumor that affects the jaws. However, recent data on this variant have all indicated aggressive behaviour characterized by an infiltrative growth pattern with a high rate of recurrence and local or. Histologically, ccoc is characterized by sheets and islands of vacuolated clear cells. The tumor was surgically excised and has not recurred or. Dec 12, 2006 background clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th7th decades and shows a female preponderance.
Although touted as a benign lesion in the initial stages, once the aggressive nature of the lesion became evident, it was reclassified as a malignant tumor by the world health. Who classification benign odontogenic epithelium without odontogenic ectomesenchyme ameloblastoma squamous odontogenic tumor pindborgs tumor clear cell odontogenic tumor odontogenic epithelium with odontogenic ectomesenchyme with or without dental hard tissue formation. Clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in. It commonly occurs in the mandible, most common age group belong between 5th and 7th decades. This article describes a case of clear cell odontogenic carcinoma ccoc in a 55yearold woman who presented such a tumor extending from the midline of the mandible to the right first molar. Ameloblastic fibroma this is a tumor of childhood, the typical patient is about 12 14 years old, seldom is it seen beyond age 20. Odontogenic tumor composed predominantly of clear cells is a rare neoplasm of the jaws that was initially designated as clear cell odontogenic tumor.
A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline. Ceot is rare and accounts for only 1% of all odontogenic tumors 1. Pdf peripheral clear cell variant of calcifying epithelial. Clear cell odontogenic carcinoma is a rare jaw lesion with predominantly clear cell characteristics. Clear cell odontogenic carcinoma ccoc malignant epithelial odontogenic neoplasm also composed primarily of clear cells, which usually occurs in anterior mandible unlike hccc, the nests or cords may show focal palisading of basal cells ameloblastic. For this purpose, a short series of di erent salivary gland, and odontogenic tumors showing prominent clear cell features was included in the study. Radiography demonstrates unilocular, and more often multilocular radiolucency.
Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring predominantly in posterior mandible during 5 th 7 th decades with a female predilection. A case of clear cell odontogenic tumor with unusual histological features is presented. A 61yearold japanese man was admitted because of swelling of the left premolarmolar region of the mandible. Clear cell odontogenic carcinoma with ghost cells and. Clear cell odontogenic carcinoma report of two cases and. Clear cell odontogenic carcinoma ccoc is a rare jaw tumor that was classified as a malignant tumor of odontogenic origin in 2005 by the world health organization because of its aggressive and destructive growth capacity and metastasis to the lungs and lymph nodes. The clear cell odontogenic tumor is described as a benign but locally invasive odontogenic tumor in the current world health organization classification for odontogenic tumors. To date, only 67 cases were described in the english literature and complete understanding of the behavior of ccoc was based on limited case reports. To date, only 67 cases have been described in the english language literature, and an understanding of the behavior of ccoc has been based on limited case reports. Pathogenesis and nomenclature of odontogenic carcinomas.
Clear cell odontogenic carcinoma ccoc is a rare malignant tumor. Mandibular clear cell odontogenic carcinoma world journal. Pdf clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis and low survival. Pdf clear cell odontogenic carcinoma of the mandible luz. In 1992, ccoc was classified as odontogenic tumor by the who 2. Odontogenic ghost cell tumour with clear cell components. Materials and methods the clinical charts of all patients with secondary neoplasms of the orofacial tissues observed. Biphasic variant of clear cell odontogenic carcinoma a case. In addition to hyalinizing clear cell carcinoma of the salivary gland, it is one of the epithelial neoplasms known to harbor an ewsr1atf1 fusion. Mar 19, 2002 an atypical case of clear cell odontogenic carcinoma occurred in the mandible of a 50. Clear cell odontogenic tumora new histologic variant with aggressive potential.
Clear cell odontogenic carcinoma is a rare neoplasm with very few cases reported in the literature. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaw with a particular histology and a deceptive behavior. Such tumors, however, are rare in the head and neck region. Clear cell odontogenic carcinoma ccoc is described as an exceptional and hard to diagnose malignant tumor which was first reported by hansen in 1985. Clear cell odontogenic carcinomas are uncommon epithelial neoplasms that have metastatic potential. Case presentation a 45 year old woman presented with a radiolucent left mandibular swelling associated with loss. It is potentially aggressive, capable of frequent recurrences and locoregional and distant metastases. Calcifying epithelial odontogenic tumor medwin publishers. This article describes a case of clear cell odontogenic carcinoma ccoc in a 55. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw described in 1985 for the first time by hansen 1. Is conservative surgery the best approach for peripheral.
Maxillary clear cell odontogenic carcinoma a rare entity. Pathology outlines clear cell carcinoma of salivary gland. Clear cell odontogenic carcinoma is a rare malignant odontogenic neoplasm, with a predilection for the anterior segment of the jaws, and presenting basically in women between the fifth and seventh. Clearcell variant of calcifying epithelial odontogenic tumor. Histologically, the tumor was composed mostly of large clear cells and squamous cells. Clear cell odontogenic carcinoma and clear cell ameloblastoma. Since clear cells are present in few odontogenic tumors. It is recommended that terms such as clear cell ameloblastoma and clear cell odontogenic tumor not be used to describe such tumors. Clear cell odontogenic carcinoma pathology outlines.
Pdf clear cell odontogenic carcinoma mimicking a cystic. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaws, histologically characterized by the presence of. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis and low survival. The tumor occurred in the anterior mandible of a 69. Dec 01, 2017 clear cell odontogenic carcinoma ccoc is described as an exceptional and hard to diagnose malignant tumor which was first reported by hansen in 1985. Tumor recurred within 5 years of its excision and histopathological examination revealed a clear cell odontogenic carcinoma. Other odontogenic lesions with clear cells including ameloblastoma and clear cell odontogenic tumors have been reclassified as malignant, in which a more aggressive course can be expected 24, 25.
Clear cell cystic variant of calcifying epithelial. Nov 01, 2019 clear cell odontogenic carcinoma ccoc is a rare intraosseous tumor of the jaws. Case report peripheral clear cell variant of calcifying. Clear cell odontogenic carcinoma american journal of. Clear cell odontogenic carcinoma of the mandible mosqueda. Therefore, a link between these tumors seems plausible. In 1992, who classified ccoc as benign odontogenic tumor however, in the who classification of 2005 it was considered to be a malignant tumor of odontogenic origin due to its aggressive nature, predilection to local recurrence, locoregional lymph node. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in females.
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